The Type III secretion system (T3SS) is an essential mechanism for host-pathogen interaction in the infection process. A figure of the T3SS machinery is displayed at the bottom of this page. The proteins secreted through the T3SS machinery of many gram negative bacteria are known as T3SS effectors (T3SEs). These can either be localized subcellularly in the host, or be part of the needle tip of the T3SS that interacts directly with the host membrane to bring other effectors into the target cell.
Due to the key role of T3SS effector proteins in the establishment and maintenance of bacterial pathogenicity, considerable research have been placed upon the identification of T3SS effectors. As such, there is a need for an effective data management system to collate and classify all relevant information concerning T3SEs.
T3SEdb represents such an effort to assemble a comprehensive database of all experimentally determined and putative T3SEs into a web-accessible site. It contains more than 1089 entries of T3SS effector sequence data including primary sequences and functional annotations. Using the data in T3SEdb, we successfully developed a predictor for T3SS effectors with an Aroc value of ~91%.
Features of T3SEdb
|Diagram illustrating the T3SS machinery
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